Author:
A. Suleiman* , M. A. Yahaya, A. S. Funmilayo
This is an open access article distributed under the Creative Commons Attribution License CC BY 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
ABSTRACT
This study aimed to assess the additive effect of Momordica charantia (bitter melon) on the lymphoid organs of diabetic guinea pigs induced by sodium glutamate. A total of 24 Guinea pigs were utilized in this 8-week study, randomly assigned to four dietary treatments (T1, T2, T3, and T4), with each treatment comprising 6 Guinea pigs, replicated thrice with 2 Guinea pigs per replicate in a completely randomized design (CRD). Following an eight-week feeding trial, two guinea pigs from each treatment group were euthanized, and their spleen, bile, kidney, heart, and lungs were harvested and weighed. The findings suggested that the additive effect of Momordica charantia (bitter melon) on the lymphoid organ of diabetic guinea pigs generated by sodium glutamate showed no significant alterations in the liver, spleen, kidney, bile, and heart. The gross anatomical and pathological lesions indicate that T4 had the largest frequency of pathological alterations in lymphoid organs, but the examination of hepatic tissues revealed no fluid accumulation, pus, or odor. The findings of this study on the kidneys and lungs revealed necrosis, edema, and hematoma. The treated groups had a significantly darker brown coloration of the liver compared to the control group. Momordica charantia exhibited a significant impact on hepatocytes, hepatocyte height, cholangiocytes, Kupffer cells, endothelial cells, and sinusoids.
| Pages | 07-09 |
| Year | 2026 |
| Issue | 1 |
| Volume | 6 |
